Search results for "Pediatric CNS"
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Doubling Recruitment of Pediatric Low-grade Glioma within Two Decades does not change Outcome – Report from the German LGG Studies
2021
Successive multicenter studies for pediatric low-grade glioma (LGG) in Germany were accompanied by a doubling of annual recruitment over 2 decades. We investigated whether this increase conveyed a change of epidemiologic characteristics or survival.Participating centers reported 4634 patients with the radiologic/histologic diagnosis of LGG (1996-2018), rising from 109 to 278/year. Relating these numbers to all pediatric CNS tumors registered at the German Childhood Cancer Registry, the LGG fraction and annual crude incidence rates increased (32% to 51%; 0.94 to 2.12/100,000 children/adolescents15 years). The consecutive LGG studies recruited 899 (HIT-LGG 1996), 1592 (SIOP-LGG 2004), and 183…
Epidemiology of pediatric tumors of the central nervous system.
2009
Tumors of the CNS are the second most frequent malignancy in childhood and the most common of the solid tumors. An increase in CNS tumor rates during the past decades has been observed in a number of countries. One possibility is that improvements in diagnostics of CNS tumors contributed to the increasing trend. Another concern is that changes in environmental exposures may be responsible for the increasing incidence rates and a number of epidemiologic studies investigated factors like exposure to ionizing radiation, electromagnetic fields, or pesticides. In addition, prenatal exposures, for example from maternal diet, or the role of infectious agents were of particular interest. In this re…